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Funded Research

FAILSAFE Funding: Accelerating Global Solutions to Antifungal Resistance

Since its launch, the FAILSAFE initiative has rapidly become a central driver of innovation in tackling the global challenge of fungal antimicrobial resistance (fAMR). Across its first two rounds of funding, FAILSAFE has supported 28 impactful projects led by researchers from 94 institutions spanning 31 countries worldwide.

With nearly £2.87 million invested, these projects range from early-stage seedcorn grants to larger-scale investigations, designed to fast-track solutions that address the disproportionate burden of fungal diseases in low- and middle-income countries (LMICs).

This broad, collaborative portfolio underpins advances across five crucial areas: understanding antifungal resistance, developing next-generation antifungals, enriching pathogen surveillance, pioneering vaccine research, and innovating diagnostics.

The diverse network of internationally-renowned institutions and researchers illustrates the program’s strength—not only funding cutting-edge science but also building a truly global community united in combatting an urgent and overlooked health crisis.

Further rounds of funding are planned and will be advertised on this website. Check back soon for updates!

For more details sign up to the CMM-FAILSAFE Medical Mycology network https://cmm-failsafe.com/become-a-member/

Looking for a quick overview of who has received FAILSAFE funding?
Explore the summaries by clicking the links below

Mid to Large grants


2024 – 2026

Miltefosine – a dual purpose antifungal to mitigate antifungal resistance

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2024-2025

Developing approaches to limit the impact of agricultural fungicides in driving clinical antifungal resistance

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2025-2026

BAL2039 -A Novel anti-Cryptococcal treatment Evaluation – pre-clinical optimization through in-vitro and animal model studies (BALANCE-1) to inform phase 2 and 3 human trials

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Seedcorn grants


2024-2025

A collection of proven, probable, possible and control cases of Fungal Disease to develop AI Fungal Disease algorithms

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2024-2025

Exploring the mechanisms behind the anti-cryptococcal potential of an extracellular vesicle tripeptide targeting dipeptidyl peptidase 4

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2024-2025

Potential of topical sapienic acid-rich lipids to prevent skin colonisation by Candida auris

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2024-2026

SCARS: Surveillance of Candida Antifungal Resistance in the Southern African Region

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2024-2025

Understanding genome and cell surface protein evolution during echinocandin-induced cell wall remodelling in Candida species to identify biomarkers for rapid detection of drug resistance

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2024-2025

In Vivo Efficacy Of An Innovative Vaccine Approach Targeting Debilitating And Life-Threatening Mucorales Infections

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2024-2025

Tackling Azole-Resistant Aspergillus fumigatus Through Environmental Monitoring and Policy

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2024-2025

Enhancing fluconazole efficacy and precision through novel molecular and nanoscale approaches

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2024-2025

Analytical validation of electrochemical immunosensor prototype for the diagnosis of Histoplasmosis

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2024-2025

Worming away at fungi: helminth secreted products as a new class of antifungal therapeutics

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2024-2025

Advancing Treatment Options for Feline Sporotrichosis: Evaluating D13 in Clinical Trials

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2024-2025

Strengthening Agricultural Biosecurity in Southeast Asia: A Multinational Biobank Initiative for WHO Filamentous Fungal Pathogens to Enhance Pathogen Monitoring and Resistance Detection

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2024-2025

Identification of new fungal Glycosylphosphatidylinositol (GPI)-anchored wall transfer protein 1 (GWT1) inhibitors

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2025-2025

Feline Assessment for Sporothricosis Testing (FAST-Cat)

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2025-2026

Expanding Wastewater Surveillance to Monitor Candida Species and Antifungal Resistance in Healthcare Settings in Southern Africa

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2025-2026

Generating and Showcasing AutoMated tool for Antifungal resistance Surveillance System (AMASS-FUNGI)

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2025-2026

Fungal Cell Wall Targeting Immunotherapies: A New Approach For The Treatment Of Drug Resistant Invasive Fungal Infections

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2025-2026

Developing novel medicines in India to treat endemic fungal infections and address the threat of antimicrobial resistance

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2025-2026

Fungal extracellular vesicles as a platform for vaccine development

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2025-2026

Repurposing CNS-penetrant therapeutics for the treatment of cerebral cryptococcosis in a mouse model of CD4 T cell deficiency

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2025-2026

Combating Candidemia: Targeting Biofilms and Antimicrobial Resistance to Reduce Incidence and Mortality in Brazil

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2025-2026

Targeting fungal keratitis in LMICs: Structure-guided optimization and in vivo validation of a novel antifungal class

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2025-2026

Development of a Nanoencapsulated Amphotericin B Formulation and Its Ex Vivo Evaluation in Porcine Skin and Mucosal Models for Mucormycosis

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2025-2026

Evaluating MMV1593537 as a Novel Antifungal Strategy Against Drug-Resistant Candidozyma (Candida) auris

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2025-2026

Exploring prevalence, genomics, clinical outcome, psychosocial, financial and quality of life impact of antifungal resistant dermatophyte infections in Pakistan

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